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Hot Sale Taltirelin with High Quality CAS 103300-74-9

Basic Info

Model No.:  cas 103300-74-9

Product Description

Model NO.: cas 103300-74-9 Customized: Non-Customized Suitable for: Adult Purity: >98% Type: Pharmaceutical Intermediate Grade: Medicine Grade CAS: 103300-74-9 Specification: 10mg/vial HS Code: 2801100000 Powder: Yes Certification: GMP, HSE, ISO 9001, USP, BP State: Solid Color: White Storage: Dry Cool Place Certificate: GMP Trademark: Filter Origin: Shanghai Product details:
Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Both antinociceptive and neuroprotective.
Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects, and little development of tolerance following prolonged dosing. It has nootropic, neuroprotective and analgesic effects.
Taltirelin, TA-0910, Ceredist,103300-74-9,C17-H23-N7-O5,(S)-1-Methyl-4,5-dihydroorotyl-L-histidyl-L-prolinamide; (S)-N-[(1-Methyl-2,6-dioxohexahydropyrimidin-4-yl)carbonyl]-L-histidyl-L-prolinamide
The methylation of 4,5-dihydroorotic acid benzyl ester (I) with methyl iodide gives the corresponding 1-methyl derivative (II), which is debenzylated by hydrogenolysis with H2 over Pd/C yielding (S)-1-methyl-4,5-dihydroorotic acid (III). Finally, this compound is condensed with L-histidyl-L-prolinamide (IV) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (HONSU) in DMF.

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